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1: Clin Cornerstone. 2003;5(4):32-8; discussion 39-40.
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Extraesophageal manifestations of gastroesophageal reflux disease.

Vaezi MF.

Center for Swallowing and Esophageal Disorders, Department of Gastroenterology and Hepatology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA. vaezim@ccf.org

Gastroesophageal reflux disease (GERD) may manifest as laryngitis, asthma, cough, or noncardiac chest pain. Diagnosing these extraesophageal manifestations may be difficult for primary care physicians because most patients do not have heartburn or regurgitation. Diagnostic tests have low specificity, and a cause-and-effect association between GERD and extraesophageal symptoms is difficult to establish. Response to aggressive acid suppression is often the best indication of GERD etiology in a patient with extraesophageal symptoms.

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PMID: 15101493 [PubMed - indexed for MEDLINE]